Research Associate (Lung Cancer and Tumour Microenvironment) (Fixed Term)
Department of Oncology
University of Cambridge
We are seeking to appoint a Research Associate to investigate in the early stages of lung cancer initiation and how it relates to tumour microenvironment. The Research Associate will be based in the laboratory of Dr Daniel Munoz-Espin, Group Leader in the Department of Oncology at the University of Cambridge. This new post funded by Cancer Research UK (CRUK) is available from 1st January 2019.
One of the main goals of the Dr Munoz-Espin’s research programme is the understanding of the mechanisms and processes that contribute to the origin of cancer at the cellular level, which remains a formidable challenge in oncology. We are looking for highly motivated researchers to work at the interface between cellular senescence, tumour microenvironment and cancer, with a focus on lung tumours. Candidates must have a PhD in the biological or biomedical sciences, and relevant experience working in cancer fundamental research, cellular biology, cell cultures and animal models. Skills in flow cytometry sorting, confocal microscopy, RNAseq experiments, proteomics analysis and manipulation of human tissue samples are desirable. Candidates must have at least one first-author research article accepted for publication in a major peer-reviewed journal. International experience and/or interconnections with the research industry would be evaluated positively.
The successful applicants will perform experiments with primary cells from human tissue samples in collaboration with the Royal Papworth Hospital Research Tissue Bank (Cambridge), and will have active access to our cancer animal models. We will employ microenvironment-microarrays (MEMA), a technology that allows us to screen thousands of unique combinations of matrix proteins and soluble ligands for their impact on tumorigenesis. This work will be done in close collaboration with the group of Dr James Korkola (Oregon Health & Science University, OHSU, Portland, USA). Availability to travel once/twice a year to Portland is required to coordinate the research between the two groups. These studies will enable us to identify new drivers of early tumorigenesis, provide novel markers for detection of early lung lesions, and provide new therapeutic targets for tumour eradication.
The laboratory of Dr Munoz-Espin (https://www.munoz-espinlab.com/ ) is part of the Early Detection Programme of the Cancer Research UK Cambridge Centre. Due to the internationally-renowned research institutions at the Cambridge Biomedical Research Campus (including the CRUK Cambridge Institute or the WT/MRC Cambridge Stem Cell Institute), the connections with Addenbrooke’s and Papworth’s hospitals, an increase in the number of biotechnology companies (such as AstraZeneca or Abcam), and the academic excellence of the University, Cambridge has become a worldwide recognised core for cancer research. Our location affords our members ready access to state-of-the-art research equipment and clinical facilities, cancer animal models, human tissue samples, and the opportunity to forge collaborations with world class laboratory scientists and clinicians.
Informal enquiries are welcomed, and should be directed to Dr Munoz-Espin at firstname.lastname@example.org.
Fixed-term: The funds for this post are available until 31 December 2020 in the first instance.
Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment and a security check.
To apply online for this vacancy and to view further information about the role, please visit:
The closing date is 4 November 2018, with interviews to be confirmed.
Please ensure that you upload a covering letter and CV in the Upload section of the online application. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
Please quote reference RD16913 on your application and in any correspondence about this vacancy.